Preface Volume 30, Issue 3

AbstractOne of the main areas of research in logic programming is the design and implementation of sequential and parallel (constraint) logic programming systems. This research goes broadly from the design and specification of novel implementation technology to its actual evaluation in real life situations. A series of workshops on Implementations of Logic Programming Systems, previously held in Budapest (1993), Ithaca (1994), Portland (1995), Bonn (1996), Port Jefferson (1997), Manchester (1998) and Las Cruces (1999) provided a forum for ongoing research on the design and implementation of sequential and parallel (constraint) logic programming systems.This volume contains a collection of papers presented at the Workshop on Parallelism and Implementation Technology for (Constraint) Logic Programming, held in Las Cruces on December 1st, 1999, in conjunction with ICLP'99. The workshop was sponsored and organised by COMPULOG AMERICAS. The workshop also received support from the Association for Logic Programming and from the Department of Computer Science, New Mexico State University.Papers from both academia and industry were invited. Preference was given to the analysis and description of implemented systems (or currently under implementation) and their associated techniques, problems found in their development or design, and steps taken towards the solution of these problems.Topics included, but were not limited to: •standard and non—standard sequential implementation schemes (e.g., generalization/modification of WAM, translation to C, etc.);implementation of parallel logic programming systems;balance between compile-time effort and run-time machinery;techniques for the implementation of different declarative programming paradigms based on, or extending, logic programming (e.g., constraint logic programming, concurrent constraint languages, equational-logic languages);performance evaluation of sequential and parallel logic programming systems, both through benchmarking and using real world applications;other implementation-related issues, such as memory management, register allocation, use of global optimisations, etc.We were very fortunate to have so many interesting research papers, ranging over widely different subjects and giving a broad coverage of current research in sequential and parallel implementation of logic programming systems. Papers on sequential logic programming systems, focus on varied topics: constraint evaluation, support for extensions to logic programming, and abstract machines for performance evaluation. Papers on parallel logic programming systems also focus on diverse topics ranging from distributed implementations, garbage collection, to optimisations for exploiting and-or parallelism.The editors would like to thank all authors that chose to submit their work to this book, and also for their cooperation in making this document possible. We would also like to thank all referees involved in assessing the papers in this special volume.This volume will be published as volume 30, Issue 3 in the series Electronic Notes in Theoretical Computer Science (ENTCS). This series is published electronically through the facilities of Elsevier Science B.V. and its auspices. The volumes in the ENTCS series can be accessed at the URL http://www.elsevier.nl/locate/entcs March 14, 2000Horst Reiche

Projeto de nação e formação econômica: é possível encontrar indícios de uma Administração Política nos planos macroeconômicos do Brasil?

O presente ensaio se preocupou em identificar, no âmbito dos planos macroeconômicos engendrados desde a implantação do modo de produção capitalista no Brasil, indícios da presença da Administração Política no país. Para tanto, realizou-se um resgate histórico do processo de acumulação capitalista desde a era Vargas, denominado de acumulação restringida, passando pelo período da substituição de importações de Juscelino Kubitschek, que marcou a fase da acumulação plena e implantou o centro dinâmico do processo de industrialização - o departamento de bens de consumo capitalista. Por fim, desemboca-se na implantação do departamento de bens de capital na gestão do presidente militar Ernesto Geisel sob o Brasil em Marcha Forçada. Acredita-se que durante o período de 1930 a 1984 houve indícios da consecução de um Projeto de Nação, mas que se perdeu a partir daí em função da força dos preceitos neoliberais cujos alicerces se fundamentam numa ideologia que enaltece apenas a busca pela estabilização (planos de controle da inflação) em detrimento do fortalecimento das relações sociais de produção mediados pelo Estado

Exercício físico e sua influência na saúde sexual

Assim como a saúde em geral, o desempenho sexual depende do bem estar físico, mental e social, sendo influenciado pelo estilo de vida, contexto no qual merece destaque a atividade física. Neste ensaio apresentamos alguns dos mecanismos pelos quais a prática regular de exercícios físicos por múltiplos mecanismos fisiológicos contribui para a saúde do corpo e da mente, e defendemos a hipótese de que a dança de salão pode ser considerada como excelente opção quando se objetiva ao mesmo tempo o aprimoramento da função cardiovascular e sexual

O processo de implantação do mapa inteligente virtual no território de abrangência no centro de saúde da família EFAPI, situado no município de Chapecó-SC

Introdução: A gestão em saúde, de forma participativa, pode ser realizada por meio da confecção de mapas para identificação das necessidades de saúde da comunidade. Neste contexto, o mapa inteligente virtual - (MIV) é uma estratégia criativa que possibilita planejar e compreender o território de forma mais eficiente. Objetivo: Reconhecer o território de abrangência do Centro de Saúde da Família (CSF) - EFAPI, através da confecção de um MIV. Metodologia: Este estudo trata-se de um relato de experiência da confecção de um MIV, realizado pelo grupo PET Interprofissionalidade. A confecção do MIV foi realizada no período de maio e junho de 2019. O grupo manteve contato as Agentes Comunitárias de Saúde (ACS), e a população, realizando reconhecimento do território. A coleta dos dados realizou-se no sistema eletrônico próprio da Secretaria Municipal de Saúde de Chapecó - WinSaúde e a confecção do mapa pela plataforma google maps, registrando em tempo real as informações que foram disponibilizadas pelas equipes do CSF. Resultados: As informações que constaram no MIV retrataram o perfil epidemiológico da comunidade como: número de pacientes com comorbidades crônicas (hipertensos, diabéticos e acamados), número de crianças menores de 2 anos, gestantes, áreas de vulnerabilidade social, focos de mosquito da dengue, locais como escolas e centros comunitários localizados no território. Considerações Finais: A produção do MIV proporcionou exercitar o trabalho efetivo em grupo através de estratégias de territorialização em saúde e obter uma visão holística e humanitária da comunidade.  Ao final da confecção do MIV os estudantes destacaram a disponibilidade e a qualidade do trabalho das ACS, auxiliando e organizando as micro áreas para potencializar a prevenção e promoção da saúde. Além de desenvolver estratégias de intervenção voltadas ao auxílio da população junto ao CSF e ainda poder oferecer maior atenção a população com às suas particularidades. Como existe variação nos dados das condições e necessidades de saúde, é importante que o MIV seja atualizado constantemente, assim possibilitará gerar relatórios de saúde ou levantamentos do comportamento populacional de saúde com dados mais precisos. Palavras-chave: Centro de Saúde. Gestão em Saúde. Agentes Comunitárias da Saúde

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction

The known breast cancer (BC) susceptibility polymorphisms in FGFR2, TNRC9/TOX3, MAP3K1,LSP1 and 2q35 confer increased risks of BC for BRCA1 or BRCA2 mutation carriers. We evaluated the associations of three additional SNPs, rs4973768 in SLC4A7/NEK10, rs6504950 in STXBP4/COX11 and rs10941679 at 5p12 and reanalyzed the previous associations using additional carriers in a sample of 12,525 BRCA1 and 7,409 BRCA2 carriers. Additionally, we investigated potential interactions between SNPs and assessed the implications for risk prediction. The minor alleles of rs4973768 and rs10941679 were associated with increased BC risk for BRCA2 carriers (per-allele Hazard Ratio (HR)=1.10, 95%CI:1.03-1.18, p=0.006 and HR=1.09, 95%CI:1.01-1.19, p=0.03, respectively). Neither SNP was associated with BC risk for BRCA1 carriers and rs6504950 was not associated with BC for either BRCA1 or BRCA2 carriers. Of the nine polymorphisms investigated, seven were associated with BC for BRCA2 carriers (FGFR2, TOX3, MAP3K1, LSP1, 2q35, SLC4A7, 5p12, p-values:7×10−11-0.03), but only TOX3 and 2q35 were associated with the risk for BRCA1 carriers (p=0.0049, 0.03 respectively). All risk associated polymorphisms appear to interact multiplicatively on BC risk for mutation carriers. Based on the joint genotype distribution of the seven risk associated SNPs in BRCA2 mutation carriers, the 5% of BRCA2 carriers at highest risk (i.e. between 95th and 100th percentiles) were predicted to have a probability between 80% and 96% of developing BC by age 80, compared with 42-50% for the 5% of carriers at lowest risk. Our findings indicated that these risk differences may be sufficient to influence the clinical management of mutation carriers

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Distributing And-Work and Or-Work in Parallel Logic Programming Systems

In parallel logic programming systems that exploit both and-parallelism and or-parallelism, a problem arises that is how to distribute processors between the dynamically varying amounts of and-work and or-work that are available. Solutions have been reported for distributing only or-work, or distributing only and-work, but the issue of distributing processors between both kinds of work has not yet been addressed. In this work we discuss the problem of distributing and-work and or-work in the context of Andorra-I, a parallel logic programming system that exploits determinate andparallelism and or-parallelism. We describe dynamic scheduling strategies that aim at efficiently distributing processors between and-work and or-work, and compare their performance with the performance produced by a static scheduling strategy, for a wide range of benchmarks